About hictoolsr

hictoolsr hictoolsr-package

hictoolsr: a set of tools for Hi-C data analysis

Extracting Hi-C Counts

extractCounts()

Extract counts from .hic file(s)

calcApa()

Extract BEDPE interactions from a Hi-C matrix

Generating Paired Interactions

calcBedpe()

Calculates all potential paired interactions from a BED file

calcPairs()

Define function to calculate all paired interactions within a windowSize

Merging/Filtering/Binning

Tools for merging, filtering, or binning paired interactions.

binBedpe()

Define function to flexibly bin bedpe data by hic resolution

filterBedpe()

Filters out short BEDPE interactions

mergeBedpe()

Read-in and merge BEDPE Interactions by Genomic distance with DBSCAN

makeGInteractionsFromDataFrame() as_ginteractions()

Convert DataFrames to GInteraction objects

binAnchor()

Define helper function for binning an anchor

check_binned()

Helper function to check that a GInteractions object has been binned

shiftAnchor()

Define helper function for flexibly shifting an anchor

Plotting Functions

plotApa()

Plots Aggregate Peak Analysis Matrix

Example Datasets

loopApaFsHic

Aggregate peak analysis of differential loop results from FS Hi-C

loopApaWtHic

Aggregate peak analysis of differential loop results from WT Hi-C

loopCounts

Merged loop calls with contact frequency from replicate Hi-C experiments